Urea 40% cream is a potent keratolytic that is not suitable for use as a regular moisturizer. Urea is a diamide of carbonic acid with the following chemical structure: Urea gently dissolves the intracellular matrix which results in loosening of the horny layer of the skin and shedding of scaly skin at regular intervals, thereby softening hyperkeratotic areas of the skin. Medically reviewed by Drugs.com. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails. Urea is now prepared commercially in vast amounts from liquid ammonia and liquid carbon dioxide. Urea, sometimes referred to as carbamide, is produced in mammalian systems when proteins are broken down. Copyright 2020 Leaf Group Ltd. / Leaf Group Media, All Rights Reserved. If redness or irritation occurs, discontinue use and consult a physician. Urea Cream 40%. For topical use only. Urea cream typically ranges from 2% to 40% in potency and is used to help soften thick layers of skin and nails, also it … Ammonia is highly toxic and would be deadly if it accumulated in the body. Avoid contact with eyes, lips or mucous membranes. Benzoyl peroxide/urea topical is used in the treatment of: Acne; chlorophyllin copper complex/papain/urea topical. Select one or more newsletters to continue. Urea is also in animal feedstock, certain plastics and glues, explosive components and commercial pro… It may also be used to soften nails. Not for ophthalmic use. La crème à l'urée à 40% est un kératolytique puissant qui ne convient pas comme crème hydratante d'usage [...] régulier. Scientist have learned to synthesize it and it is used for many different purposes. The urea cycle starts with deamination, when the liver breaks down amino acids to make ammonia. The discovery impressed scientists because it was thought that a mysterious "vital force" was needed to make the substances found in the human body. In its most concentrated form, it is urine. Ammonium cyanate is urea." Urea also acts to remove dead skin, states the University of Pittsburgh Medical Center. Brand names: Panafil, Panafil SE, AllanfillEnzyme, Gladase-C Drug class(es): topical debriding agents Chlorophyllin copper complex/papain/urea topical is used in the treatment of: Burns, External; Dermatologic Lesion; Wound Cleansing Royal Society of Chemistry: Excretion and the Liver, University of Bristol School of Chemistry: Urea, The George Washington University: Urea Cycle Disorders. No representation is made as to generic status or bioequivalency. The mechanism of action of topically applied urea is not yet known. No representation is made as to generic status or bioequivalency. In its most concentrated form, it is urine. People often get confused by these, but they are, in fact, … Made in Italy Intensive and nourishing cream for cracked heel 75 ml . Urea is of major historical significance. (198.4 g): NDC 16477-340-07 Store at room temperature 15°C - 30°C (59°F - 86°F). The German chemist Friedrich Wohler in 1828 attempted to make ammonium cyanate from silver cyanide and ammonium chloride and, in the process, accidentally made urea. Rx Only For external use only. Urea 40% Cream … WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Apply to diseased or damaged nail(s) twice per day, or as directed by a physician. Description. KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. Yes, the urea that is used in topical dermatological formulas like your prescription lotion is definitely synthetically produced. Each person recommending a prescription substitution using this product shall make such recommendations based on each person's professional opinion and knowledge, upon evaluation of the active ingredients, excipients, inactive ingredients and chemical information provided herein. Urea 40% emulsion: Urea 40% suspension: Urea 42% pad: Urea 45% gel: Urea 50% cream: Urea 50% gel: Apply to nail tissue or affected skin twice/day. Pregnancy Category B. Urea also makes it easier to add certain ingredients to a … How does Urea work? Of course, the urea that’s used is synthetic. skinpharmacies.ca . Urea is synthesized in the body of many organisms as part of the urea cycle, either from the oxidation of amino acids or from ammonia. Not for ophthalmic use. It is formed from ammonia and carbon dioxide and can be produced in either a solid or liquid form. Urea is a crystalline compound, and the nitrogen content is always at least 46 percent when dry. 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